This Chicken and Spinach Casserole with Cream Cheese blends juicy chicken, sautéed spinach, and a creamy cheese sauce into one irresistible baked dish. It’s the kind of warm, hearty meal that fits perfectly into busy weeknights or meal prep routines. If you enjoy cozy casseroles, you’ll also love our Cheeseburger French Fry Casserole or One Pan Ground Chicken Casserole.
Table of Contents
Why You’ll Love This Creamy Chicken Spinach Casserole
This recipe is a family favorite because it’s simple to make, satisfying, and packed with creamy flavor. Plus, it’s naturally low-carb and high-protein. Want more protein-packed ideas? Try our Protein-Packed Yogurt Bowl for breakfast or a Sweet Potato Taco Bowl for lunch.
Ingredients
- 2 cups shredded cooked chicken
- 10 oz fresh or frozen spinach, drained
- 8 oz cream cheese, softened
- 1/2 cup heavy cream or milk
- 1/2 cup shredded mozzarella
- 1/4 cup grated Parmesan
- 2 cloves garlic, minced
- 1/2 small onion, chopped
- 1 tbsp olive oil or butter
- 1/2 tsp Italian seasoning
- Salt & pepper to taste
For more creamy meals, you may love our Creamy Mushroom and Spinach Stuffed Chicken or Creamy Basil Pesto Chicken.
Kitchen Tools You’ll Need
- Skillet
- Mixing bowl
- 9×13” baking dish
- Whisk or spatula
- Oven
Short on time? Try our Freezer Breakfast Sandwiches for a make-ahead option that’s just as satisfying.
How to Make Chicken Spinach Casserole
- Preheat oven to 375°F.
- Sauté onion in olive oil until soft. Add garlic and spinach until wilted.
- In a bowl, whisk cream cheese and cream until smooth.
- Stir in chicken, spinach mixture, and seasonings.
- Pour into a greased baking dish.
- Top with mozzarella and Parmesan.
- Bake 25–30 minutes until golden and bubbly.
Serve it with a crisp Cucumber Caesar Salad or buttery Garlic Butter Bread Rolls to round out the meal.
Tips for the Creamiest Casserole
- Soften cream cheese before mixing for a smooth sauce.
- Squeeze out all water from frozen spinach to avoid sogginess.
- Add red pepper flakes or paprika for a spicy kick.
- Love casseroles? Check out our Eggs Benedict Croissant Casserole next.
Healthy Additions and Swaps
To lighten things up, use reduced-fat cream cheese or swap cream for milk. Add mushrooms or cauliflower for volume. For another nourishing meal, try our Harvest Quinoa Salad or Chickpea Feta Avocado Salad.
Want more veggie-packed dinner ideas? Our Stuffed Acorn Squash and Roasted Butternut Squash Salad are perfect.
Best Side Dishes to Pair
Pair this creamy casserole with:
For a fresh side, try our Fall Fruit Salad or Street Corn Creamy Cucumber Salad.
Make Ahead & Storage Tips
- Assemble up to 2 days in advance and refrigerate.
- Freeze before baking (up to 3 months). Thaw overnight before baking.
- Store leftovers in the fridge for up to 4 days.
Reheat gently in the oven or microwave. It’s also delicious cold over a bed of greens like in this Jennifer Aniston Salad.
Common Mistakes to Avoid
- Don’t skip draining the spinach—extra water will ruin the texture.
- Avoid overbaking to keep it creamy.
- Always taste and season before baking.
If you love this creamy texture, you’ll want to try our Creamy Mushroom Pasta or Spinach Artichoke Pull-Apart Bread.
FAQ
Can I use rotisserie chicken?
Yes! Rotisserie makes this even easier.
Can I use frozen spinach?
Definitely—just thaw and squeeze it well.
Can I make it vegetarian?
Substitute chicken for white beans or roasted cauliflower.
Is it low carb?
Yes! This is a high-protein, low-carb casserole.
Looking for more high-protein meals? Try our High Protein Egg Salad or Chicken Gyro Bowls.
Try This Cozy Classic Tonight
This Chicken and Spinach Casserole with Cream Cheese is creamy, comforting, and easy to love. With minimal prep and maximum flavor, it’s sure to become a regular in your rotation.
Love this kind of dinner? Explore more in our Dinner Recipe Collection or check out another cozy meal like French Onion Chicken Rice.
Print
Chicken and Spinach Casserole with Cream Cheese – The Ultimate Comfort Food
- Total Time: 45 minutes
- Yield: 6 servings 1x
Description
This Chicken and Spinach Casserole with Cream Cheese is a rich, creamy, and protein-packed comfort dish made with tender shredded chicken, fresh spinach, and a luscious blend of cream cheese and mozzarella. Perfect for busy weeknights, meal prep, or family dinners, it’s low in carbs and full of flavor.
Ingredients
- 2 large chicken breasts, cooked and shredded
- 10 oz fresh spinach (or 10 oz frozen spinach, thawed and drained)
- 8 oz cream cheese, softened
- 1/2 cup heavy cream or whole milk
- 1/2 cup shredded mozzarella cheese
- 1/4 cup grated Parmesan cheese
- 2 cloves garlic, minced
- 1/2 small onion, finely diced
- 1 tablespoon olive oil or butter
- 1/2 teaspoon Italian seasoning
- Salt and black pepper to taste
Instructions
- Preheat Oven: Preheat oven to 375°F (190°C) and lightly grease a 9×13 baking dish.
- Sauté Aromatics: In a skillet over medium heat, warm olive oil or butter. Add diced onion and cook until softened. Stir in garlic and cook until fragrant. Add spinach and cook until wilted (or fully heated if using frozen spinach).
- Prepare Cream Mixture: In a large bowl, whisk softened cream cheese with heavy cream until smooth.
- Combine: Fold in shredded chicken, sautéed spinach mixture, Italian seasoning, salt, and pepper.
- Assemble: Transfer mixture to baking dish. Top evenly with mozzarella and Parmesan cheese.
- Bake: Bake uncovered for 25–30 minutes until cheese is melted and bubbly. Let rest 5–10 minutes before serving.
Notes
- Drain spinach well to prevent excess moisture.
- Make ahead: Assemble and refrigerate up to 48 hours before baking.
- Low carb friendly: Serve with roasted vegetables or salad.
- Storage: Refrigerate leftovers up to 4 days or freeze up to 3 months.
- Prep Time: 15 minutes
- Cook Time: 30 minutes
- Category: Main Dish
- Method: Baked
- Cuisine: American
Nutrition
- Serving Size: 1 portion (1/6 of casserole)
- Calories: 385
- Sugar: 2g
- Sodium: 520mg
- Fat: 25g
- Saturated Fat: 14g
- Unsaturated Fat: 9g
- Trans Fat: 0g
- Carbohydrates: 6g
- Fiber: 1g
- Protein: 36g
- Cholesterol: 125mg
